DESCRIPTION. SINEQUAN® (doxepin hydrochloride) is one of a class of psychotherapeutic agents known as dibenzoxepin tricyclic compounds. The molecular formula of the compound is C19H21NO•HCl having a molecular weight of 316. Free E-newsletter Subscribe to Housecall. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sign up now Doxepin is a medication used to treat major depressive disorder, anxiety disorders, chronic hives, and trouble sleeping. For hives it is a less preferred option to antihistamines. For sleeping problems it has a mild to moderate benefit. As a cream it is used for itchiness due to atopic dermatitis or lichen simplex chronicus. Contains Nonbinding Recommendations. Draft Guidance on. Doxepin Hydrochloride. This draft guidance, once finalized, will represent the Food and Drug Administration's (FDA's) Find patient medical information for Doxepin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. For those who are first beginning anxiety treatment with BuSpar, dosage recommendations usually start with a low amount of the drug. If, after taking 7.5 mg twice daily, symptoms of anxiety do not improve, your healthcare provider may gradually increase your dose up to 60 mg. Detailed Doxepin dosage information for adults and the elderly. Includes dosages for Depression, Anxiety and Insomnia; plus renal, liver and dialysis adjustments. Doxepin oral capsule is only available as a generic drug. It’s not available as a brand-name drug. Doxepin comes in three oral forms: capsule, tablet, and solution. It also comes as a cream. Physician reviewed doxepin (Sinequan) (Sinequan) patient information - includes doxepin (Sinequan) description, dosage and directions. Recommended dosage As with any antidepressant, doxepin must be carefully adjusted by the physician to produce the desired therapeutic effect.